DNMT3a Expression Pattern and Its Prognostic Value in Lung Adenocarcinoma

Highlights • DNMT3a shows significantly higher expression in the lepidic subtype of lung adenocarcinoma than in the other subtypes. • High DNMT3a expression in lung adenocarcinoma is associated with favorable outcome. • DNMT3a expression is an independent prognostic marker in lung adenocarcinoma....

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-07, Vol.97, p.59-65
Main Authors: Husni, Ryan Edbert, Shiba-Ishii, Aya, Iiyama, Shinji, Shiozawa, Toshihiro, Kim, Yunjung, Nakagawa, Tomoki, Sato, Taiki, Kano, Junko, Minami, Yuko, Noguchi, Masayuki
Format: Article
Language:English
Subjects:
Adenocarcinoma - genetics
Adenocarcinoma - mortality
Adenocarcinoma - physiopathology
Adenocarcinoma - surgery
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
DNA (Cytosine-5-)-Methyltransferases - metabolism
DNA Modification Methylases - metabolism
DNMT3a
Epigenomics
Expression pattern
Female
Hematology, Oncology and Palliative Medicine
Humans
Lung adenocarcinoma
Lung Neoplasms - genetics
Lung Neoplasms - mortality
Lung Neoplasms - physiopathology
Lung Neoplasms - surgery
Male
Middle Aged
Prognosis
Pulmonary/Respiratory
Survival Analysis
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Summary:Highlights • DNMT3a shows significantly higher expression in the lepidic subtype of lung adenocarcinoma than in the other subtypes. • High DNMT3a expression in lung adenocarcinoma is associated with favorable outcome. • DNMT3a expression is an independent prognostic marker in lung adenocarcinoma.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.04.018