The relation between histopathological classification and renal outcome, ANCA subtype and treatment regimens in ANCA-associated vasculitis

ANCA-associated vasculitis (AAV) is associated with an increased risk of death and end stage renal disease (ESRD). The aim of this study was to examine the correlation between a histopathological classification and renal outcome and to describe the interaction with ANCA subtype and initial treatment...

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Bibliographic Details
Published in:Clinical and experimental rheumatology 2016-05, Vol.34 (3 Suppl 97), p.S105-S110
Main Authors: Kristensen, Tilde, Gregersen, Jon W, Krag, Søren R P, Ivarsen, Per
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - therapy
Antibodies, Antineutrophil Cytoplasmic - classification
Biopsy
Female
Glomerular Filtration Rate
Humans
Kidney - pathology
Kidney Failure, Chronic - etiology
Male
Middle Aged
Retrospective Studies
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Summary:ANCA-associated vasculitis (AAV) is associated with an increased risk of death and end stage renal disease (ESRD). The aim of this study was to examine the correlation between a histopathological classification and renal outcome and to describe the interaction with ANCA subtype and initial treatment. Eighty-seven patients with AAV from 1999-2010 from two centres in Denmark were included in the study and had a 3 year follow-up. Data was collected retrospectively. The renal biopsies were reclassi ed into one of the following groups: crescentic, sclerotic, focal and mixed. Histopathologic groups were not associated with eGFR at three years. Age and baseline eGFR were independent prognostic for eGFR at three years. More patients in the crescentic group than in the mixed and focal groups developed ESRD (33%, 13% and 5% respectively). Patients reaching ESRD had few- er non-affected glomeruli (14 % vs. 34%, p=0.0014) and lower eGFR at baseline (7 vs. 21.7 ml/min/m(2), p
ISSN:0392-856X