Palladium N-heterocyclic carbene catalyzed regioselective thiolation of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones using aryl thiols

A palladium N-heterocyclic carbene [Pd(NHC)Cl2] complex of Vitamin B1 developed earlier in our lab was also found to be an effective catalyst for regioselective thiolation via C–H bond activation of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones 1a–c using aryl thiols 2a–e. The protocol was found to be simpl...

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Bibliographic Details
Published in:Tetrahedron 2016-02, Vol.72 (8), p.1114-1119
Main Authors: Purohit, Vishal B., Karad, Sharad C., Patel, Kirit H., Raval, Dipak K.
Format: Article
Language:English
Subjects:
Activation
Aromatic compounds
Bonding
Carbenes
C–H activation
N-heterocyclic carbene
Palladium
Regioselective thiolation
Tetrahedrons
Thiols
Vitamin B1
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Summary:A palladium N-heterocyclic carbene [Pd(NHC)Cl2] complex of Vitamin B1 developed earlier in our lab was also found to be an effective catalyst for regioselective thiolation via C–H bond activation of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones 1a–c using aryl thiols 2a–e. The protocol was found to be simple, efficient and highly regioselective to afford the target products 3a–o in good to excellent yields. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2016.01.012