Biomimetic protein-based elastomeric hydrogels for biomedical applications

The biomimetic elastin, resilin, and flagelliform spider silkbased elastomeric hydrogels display remarkable self‐assembly behaviour, tunable 3D porous structure, high resilience, fatigue life, high water uptake, excellent biocompatibility and biological activity In recent years, protein‐based elasto...

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Bibliographic Details
Published in:Polymer international 2014-09, Vol.63 (9), p.1545-1557
Main Authors: Whittaker, Jasmin, Balu, Rajkamal, Choudhury, Namita R., Dutta, Naba K.
Format: Article
Language:English
Subjects:
Applied sciences
Bacteria
Biological
Biological and medical sciences
Biomedical materials
biomimetic proteins
Elastomers
Exact sciences and technology
Hydrogels
Medical sciences
Natural polymers
Organic polymers
Physicochemistry of polymers
Properties and characterization
Proteins
regenerative medicine
Resilience
Self assembly
Solution and gel properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Three dimensional
tissue engineering
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Summary:The biomimetic elastin, resilin, and flagelliform spider silkbased elastomeric hydrogels display remarkable self‐assembly behaviour, tunable 3D porous structure, high resilience, fatigue life, high water uptake, excellent biocompatibility and biological activity In recent years, protein‐based elastomeric hydrogels have gained increased research interest in biomedical applications for their remarkable self‐assembly behaviour, tunable 3D porous structure, high resilience (elasticity), fatigue lifetime (durability), water uptake, excellent biocompatibility and biological activity. The proteins and polypeptides can be derived naturally (animal or insect sources) or by recombinant (bacterial expression) routes and can be crosslinked via physical or chemical approaches to obtain elastomeric hydrogels. Here we review and present the recent accomplishments in the synthesis, fabrication and biomedical applications of protein‐based elastomeric hydrogels such as elastin, resilin, flagelliform spider silk and their derivatives. © 2013 Society of Chemical Industry
ISSN:0959-8103
1097-0126
DOI:10.1002/pi.4670