Rheological behavior and Ibuprofen delivery applications of pH responsive composite alginate hydrogels

• Published in: Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-03, Vol.139, p.211-218
• Main Authors: Jabeen, Suraya, Maswal, Masrat, Chat, Oyais Ahmad, Rather, Ghulam Mohammad, Dar, Aijaz Ahmad
• Format: Article
• Language: English
• Subjects: Acrylates - chemistry; Alginates; Alginates - chemistry; Cyclodextrins - chemistry; Drug Carriers; Drug Compounding; Drug delivery systems; Drug Liberation; Elasticity; Encapsulation; Encapsulation capacity; Glucuronic Acid - chemistry; Hexuronic Acids - chemistry; Hydrogel; Hydrogels; Hydrogels - chemistry; Hydrogen-Ion Concentration; Ibuprofen; Ibuprofen - chemistry; Kinetics; Phase Transition; Polyethylene Glycols - chemistry; Rheological properties; Rheology; Sodium alginate; Swelling ratio; Temperature; Tensile Strength; Viscosity
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2015.12.013

[Display omitted] •Chemical structure and properties of composite hydrogel depends on pH of medium.•An elastic composite hydrogel of Sod.Alginate is formed at acidic pH.•The hydrogel formulated at pH 7 is viscoelastic with better drug loading capacity.•The hydrogel synthesized at higher pH is more liquid like with reduced stability.•Drug release kinetics also depends on the pH of the synthetic medium of hydrogel. Synthesis and structural characterization of hydrogels composed of sodium alginate, polyethylene oxide and acrylic acid with cyclodextrin as the hydrocolloid prepared at different pH values is presented. The hydrogels synthesized show significant variations in rheological properties, drug encapsulation capability and release kinetics. The hydrogels prepared at lower pH (pH 1) are more elastic, have high tensile strength and remain almost unaffected by varying temperature or frequency. Further, their Ibuprofen encapsulation capacity is low and releases it slowly. The hydrogel prepared at neutral pH (pH 7) is viscoelastic, thermo-reversible and also exhibits sol–gel transition on applying frequency and changing temperature. It shows highest Ibuprofen encapsulation capacity and also optimum drug release kinetics. The hydrogel prepared at higher pH (pH 12) is more viscous, has low tensile strength, is unstable to change in temperature and has fast drug release rate. The study highlights the pH responsiveness of three composite alginate hydrogels prepared under different conditions to be employed in drug delivery applications.