Design of tissue engineering scaffolds based on hyperbolic surfaces: Structural numerical evaluation

Abstract Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaf...

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Bibliographic Details
Published in:Medical engineering & physics 2014-08, Vol.36 (8), p.1033-1040
Main Authors: Almeida, Henrique A, Bártolo, Paulo J
Format: Article
Language:English
Subjects:
Algorithms
Biomimetic Materials - chemistry
Computer Simulation
Design analysis
Design engineering
Elastic Modulus
Finite Element Analysis
Hyperbolic surfaces
Materials Testing - methods
Mathematical analysis
Mathematical models
Mechanical properties
Numerical simulation
Porosity
Radiology
Scaffolds
Software
Structural analysis
Tensile Strength
Tissue engineering
Tissue Engineering - methods
Tissue Scaffolds - chemistry
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Summary:Abstract Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds. This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour.
ISSN:1350-4533
1873-4030
DOI:10.1016/j.medengphy.2014.05.006