Serum Tumor Markers in Hemodialysis Patients

Aims The main objective of this work was to evaluate the influence of end-stage renal disease (ESRD) on concentrations of five tumor markers (TMs): carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 (CA19-9), CA15-3, CA125, and prostate specific antigen (PSA) in a group of chronic hemodi...

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Bibliographic Details
Published in:International journal of artificial organs 2014-02, Vol.37 (2), p.126-132
Main Authors: Maoujoud, Omar, Machtani, Samira El, Asseraji, Mohammed, Atbib, Yassine, Zajjari, Yassir, Taoufik, Aatif, Elbouaiti, Elarabi, Zouhair, Oualim, Benyahia, Mohammed, Tellal, Saida
Format: Article
Language:English
Subjects:
Adult
Antigens
Artificial organs
Biomarkers, Tumor - analysis
Biomarkers, Tumor - blood
CA-125 Antigen - blood
CA-19-9 Antigen - blood
Carbohydrates
Carcinoembryonic Antigen - blood
CHP
Female
Humans
Kidney Failure, Chronic - metabolism
Male
Markers
Middle Aged
Mucin-1 - blood
Patients
Prostate-Specific Antigen - blood
Renal Dialysis - methods
Reproducibility of Results
Serums
Tumors
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Summary:Aims The main objective of this work was to evaluate the influence of end-stage renal disease (ESRD) on concentrations of five tumor markers (TMs): carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9 (CA19-9), CA15-3, CA125, and prostate specific antigen (PSA) in a group of chronic hemodialysis patients (CHPs); and to study the influence of hemodialysis (HD) sessions on concentrations of the same TMs. Methods We compared TMs levels in CHP before HD sessions to a control group of 50 healthy volunteers, the dosages were determined before and immediately after the HD session Comparisons were made before and after correction for dialysis-induced hemoconcentrations. Results We enrolled 74 CHPs, all TM concentrations were higher in this group compared to control group, but this increase was significant for CEA (4.25 ± 2.89 vs 2.41 ± 1.81ng/ml; p
ISSN:0391-3988
1724-6040
DOI:10.5301/ijao.5000266