Collagen-chitosan scaffold modified with Au and Ag nanoparticles: Synthesis and structure

•Biocompatible collagen-chitosan scaffolds were modified by Au and Ag nanoparticles via the metal-vapor synthesis.•Structural and morphological parameters of the nanocomposites were assessed using a set of modern instrumental techniques, including electron microscopy, X-ray diffraction, small-angle...

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Bibliographic Details
Published in:Applied surface science 2016-03, Vol.366, p.365-371
Main Authors: Rubina, M.S., Kamitov, E.E., Zubavichus, Ya. V., Peters, G.S., Naumkin, A.V., Suzer, S., Vasil’kov, A.Yu
Format: Article
Language:English
Subjects:
Agglomeration
Collagen-chitosan scaffolds
Gold
Metal-vapor synthesis
Nanocomposite materials
Nanoparticles
SAXS
Scaffolds
Silver
Synthesis
X-ray photoelectron spectroscopy
XANES/EXAFS
XPS
XRD
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Summary:•Biocompatible collagen-chitosan scaffolds were modified by Au and Ag nanoparticles via the metal-vapor synthesis.•Structural and morphological parameters of the nanocomposites were assessed using a set of modern instrumental techniques, including electron microscopy, X-ray diffraction, small-angle X-ray scattering, EXAFS, XPS.•Potential application of the nanocomposites are envisaged. Nowadays, the dermal biomimetic scaffolds are widely used in regenerative medicine. Collagen-chitosan scaffold one of these materials possesses antibacterial activity, good compatibility with living tissues and has been already used as a wound-healing material. In this article, collagen-chitosan scaffolds modified with Ag and Au nanoparticles have been synthesized using novel method - the metal-vapor synthesis. The nanocomposite materials are characterized by XPS, TEM, SEM and synchrotron radiation-based X-ray techniques. According to XRD data, the mean size of the nanoparticles (NPs) is 10.5nm and 20.2nm in Au-Collagen-Chitosan (Au-СollСh) and Ag-Сollagen-Сhitosan (Ag-CollCh) scaffolds, respectively in fair agreement with the TEM data. SAXS analysis of the composites reveals an asymmetric size distribution peaked at 10nm for Au-CollCh and 25nm for Ag-CollCh indicative of particle's aggregation. According to SEM data, the metal-carrying scaffolds have layered structure and the nanoparticles are rather uniformly distributed on the surface material. XPS data indicate that the metallic nanoparticles are in their unoxidized/neutral states and dominantly stabilized within the chitosan-rich domains.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2016.01.107