THE USE OF CITRIC ACID DIALYSATE IN OUR DIALYSIS CENTER: PRELIMINARY EXPERIENCE

Background: Citric acid dialysate (CD) is a dialysis acid concentrate for bicarbonate-based dialysis containing citrate instead of acetate as the primary acidifying agent. The aim of our study was to compare the impact of citrate- and acetate-based dialysates on acid-base status, rate of inflammatio...

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Published in:International journal of artificial organs 2014-01, Vol.37 (8), p.617-617
Main Authors: Romozi, K, Ponikvar, R, Gubensek, J, Knap, B, Marn, A, Kveder, M, Lesevic, N, Skofic, N, Zupunski, A, Benedik, M, Buturovic, J
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Language:English
Subjects:
Acetates
Bicarbonates
Calcium
Citrates
Citric acid
Dialysis
Patients
Switching
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container_issue 8
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container_title International journal of artificial organs
container_volume 37
creator Romozi, K
Ponikvar, R
Gubensek, J
Knap, B
Marn, A
Kveder, M
Lesevic, N
Skofic, N
Zupunski, A
Benedik, M
Buturovic, J
description Background: Citric acid dialysate (CD) is a dialysis acid concentrate for bicarbonate-based dialysis containing citrate instead of acetate as the primary acidifying agent. The aim of our study was to compare the impact of citrate- and acetate-based dialysates on acid-base status, rate of inflammation, calcium balance and dialysis efficiency. Methods: We retrospectively evaluated 99 chronic hemodialysis patients treated during the months of Dec 2012 and Sept 2013. Before the switch to CD, all of the clinics used regular bicarbonate dialysate acidified with acetic acid. Regular pre-dialysis biochemical data were gathered a month before and after switching to CD. Results: Subjects were 63% male, mean age was 62 + or - 15 (range 26-92) years. After switching to CD, there was an increase in total CO sub(2) level from 22.9 + or - 3 to 24.8 + or - 3.7 mmol/l (p
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The aim of our study was to compare the impact of citrate- and acetate-based dialysates on acid-base status, rate of inflammation, calcium balance and dialysis efficiency. Methods: We retrospectively evaluated 99 chronic hemodialysis patients treated during the months of Dec 2012 and Sept 2013. Before the switch to CD, all of the clinics used regular bicarbonate dialysate acidified with acetic acid. Regular pre-dialysis biochemical data were gathered a month before and after switching to CD. Results: Subjects were 63% male, mean age was 62 + or - 15 (range 26-92) years. After switching to CD, there was an increase in total CO sub(2) level from 22.9 + or - 3 to 24.8 + or - 3.7 mmol/l (p&lt;0.001), CRP values decreased from 28 + or - 36 to 16 + or - 11 mg/l (p = 0.079), serum calcium remained unchanged (2.13 + or - 0.2 pre-CD, 2.14 + or - 0.2 mmol/l with CD, p = 0.74), troponin I levels were within normal parameters in both groups, concentration of phosphate was 1,56 + or - 0.43 pre-CD, 1.6 + or - 0.47 with CD (p = 0.54). iPTH levels were reduced from 342 + or - 357 to 314 + or - 375 pg/ml (p = 0.59). There was a minor decrease of serum creatinine and BUN concentrations after switching to CD (817 + or - 243 to 793 + or - 236 mu mol/l, p = 0.48 and 27.2 + or - 7.2 to 26.7 + or - 6.9 mmol/l, p = 0.62), while the levels of potassium in creased (5.44 + or - 0.89 to 5.65 + or - 0.95 mmol/l, p = 0.119). Conclusions: Data suggest that the substitution of citrate for acetate in dialysis fluids may improve acid-base status and level of inflammation in maintenance hemodialysis patients.</description><identifier>ISSN: 0391-3988</identifier><identifier>DOI: 10.5301/ijao.5000347</identifier><language>eng</language><subject>Acetates ; Bicarbonates ; Calcium ; Citrates ; Citric acid ; Dialysis ; Patients ; Switching</subject><ispartof>International journal of artificial organs, 2014-01, Vol.37 (8), p.617-617</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Romozi, K</creatorcontrib><creatorcontrib>Ponikvar, R</creatorcontrib><creatorcontrib>Gubensek, J</creatorcontrib><creatorcontrib>Knap, B</creatorcontrib><creatorcontrib>Marn, A</creatorcontrib><creatorcontrib>Kveder, M</creatorcontrib><creatorcontrib>Lesevic, N</creatorcontrib><creatorcontrib>Skofic, N</creatorcontrib><creatorcontrib>Zupunski, A</creatorcontrib><creatorcontrib>Benedik, M</creatorcontrib><creatorcontrib>Buturovic, J</creatorcontrib><title>THE USE OF CITRIC ACID DIALYSATE IN OUR DIALYSIS CENTER: PRELIMINARY EXPERIENCE</title><title>International journal of artificial organs</title><description>Background: Citric acid dialysate (CD) is a dialysis acid concentrate for bicarbonate-based dialysis containing citrate instead of acetate as the primary acidifying agent. The aim of our study was to compare the impact of citrate- and acetate-based dialysates on acid-base status, rate of inflammation, calcium balance and dialysis efficiency. Methods: We retrospectively evaluated 99 chronic hemodialysis patients treated during the months of Dec 2012 and Sept 2013. Before the switch to CD, all of the clinics used regular bicarbonate dialysate acidified with acetic acid. Regular pre-dialysis biochemical data were gathered a month before and after switching to CD. Results: Subjects were 63% male, mean age was 62 + or - 15 (range 26-92) years. After switching to CD, there was an increase in total CO sub(2) level from 22.9 + or - 3 to 24.8 + or - 3.7 mmol/l (p&lt;0.001), CRP values decreased from 28 + or - 36 to 16 + or - 11 mg/l (p = 0.079), serum calcium remained unchanged (2.13 + or - 0.2 pre-CD, 2.14 + or - 0.2 mmol/l with CD, p = 0.74), troponin I levels were within normal parameters in both groups, concentration of phosphate was 1,56 + or - 0.43 pre-CD, 1.6 + or - 0.47 with CD (p = 0.54). iPTH levels were reduced from 342 + or - 357 to 314 + or - 375 pg/ml (p = 0.59). There was a minor decrease of serum creatinine and BUN concentrations after switching to CD (817 + or - 243 to 793 + or - 236 mu mol/l, p = 0.48 and 27.2 + or - 7.2 to 26.7 + or - 6.9 mmol/l, p = 0.62), while the levels of potassium in creased (5.44 + or - 0.89 to 5.65 + or - 0.95 mmol/l, p = 0.119). Conclusions: Data suggest that the substitution of citrate for acetate in dialysis fluids may improve acid-base status and level of inflammation in maintenance hemodialysis patients.</description><subject>Acetates</subject><subject>Bicarbonates</subject><subject>Calcium</subject><subject>Citrates</subject><subject>Citric acid</subject><subject>Dialysis</subject><subject>Patients</subject><subject>Switching</subject><issn>0391-3988</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNjMtOAjEAAHvQRERvfkCPXhb72L68bUqRJusu6ZZETqSWNoGgi1b-34N8gKdJJpMB4AGjGaMIP-0PYZwxhBCtxRWYIKpwRZWUN-C2lANCmNc1m4DeLw1cDwb2C6itd1bDRts5nNum3QyNN9B2sF-7i7AD1Kbzxj3DlTOtfbVd4zbQvK2Ms6bT5g5c53As6f7CKfAL4_WyavsXq5u2OnGOqyhJ4AxLmnY4JcwzCTIQWu9UQjGGoFgknPDIBJZK8CTjO8sihyxkDDQrOgWPf9vT9_h1TuVn-7EvMR2P4TON57LFQlEiGZL4HykhWHAkOf0F1iJWhw</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Romozi, K</creator><creator>Ponikvar, R</creator><creator>Gubensek, J</creator><creator>Knap, B</creator><creator>Marn, A</creator><creator>Kveder, M</creator><creator>Lesevic, N</creator><creator>Skofic, N</creator><creator>Zupunski, A</creator><creator>Benedik, M</creator><creator>Buturovic, J</creator><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20140101</creationdate><title>THE USE OF CITRIC ACID DIALYSATE IN OUR DIALYSIS CENTER: PRELIMINARY EXPERIENCE</title><author>Romozi, K ; Ponikvar, R ; Gubensek, J ; Knap, B ; Marn, A ; Kveder, M ; Lesevic, N ; Skofic, N ; Zupunski, A ; Benedik, M ; Buturovic, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p661-c82a65183ed1ee16f2a8a234d9e0ccaa95c2626c5718976e8cb5f7faf78ca3f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetates</topic><topic>Bicarbonates</topic><topic>Calcium</topic><topic>Citrates</topic><topic>Citric acid</topic><topic>Dialysis</topic><topic>Patients</topic><topic>Switching</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romozi, K</creatorcontrib><creatorcontrib>Ponikvar, R</creatorcontrib><creatorcontrib>Gubensek, J</creatorcontrib><creatorcontrib>Knap, B</creatorcontrib><creatorcontrib>Marn, A</creatorcontrib><creatorcontrib>Kveder, M</creatorcontrib><creatorcontrib>Lesevic, N</creatorcontrib><creatorcontrib>Skofic, N</creatorcontrib><creatorcontrib>Zupunski, A</creatorcontrib><creatorcontrib>Benedik, M</creatorcontrib><creatorcontrib>Buturovic, J</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romozi, K</au><au>Ponikvar, R</au><au>Gubensek, J</au><au>Knap, B</au><au>Marn, A</au><au>Kveder, M</au><au>Lesevic, N</au><au>Skofic, N</au><au>Zupunski, A</au><au>Benedik, M</au><au>Buturovic, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE USE OF CITRIC ACID DIALYSATE IN OUR DIALYSIS CENTER: PRELIMINARY EXPERIENCE</atitle><jtitle>International journal of artificial organs</jtitle><date>2014-01-01</date><risdate>2014</risdate><volume>37</volume><issue>8</issue><spage>617</spage><epage>617</epage><pages>617-617</pages><issn>0391-3988</issn><abstract>Background: Citric acid dialysate (CD) is a dialysis acid concentrate for bicarbonate-based dialysis containing citrate instead of acetate as the primary acidifying agent. The aim of our study was to compare the impact of citrate- and acetate-based dialysates on acid-base status, rate of inflammation, calcium balance and dialysis efficiency. Methods: We retrospectively evaluated 99 chronic hemodialysis patients treated during the months of Dec 2012 and Sept 2013. Before the switch to CD, all of the clinics used regular bicarbonate dialysate acidified with acetic acid. Regular pre-dialysis biochemical data were gathered a month before and after switching to CD. Results: Subjects were 63% male, mean age was 62 + or - 15 (range 26-92) years. After switching to CD, there was an increase in total CO sub(2) level from 22.9 + or - 3 to 24.8 + or - 3.7 mmol/l (p&lt;0.001), CRP values decreased from 28 + or - 36 to 16 + or - 11 mg/l (p = 0.079), serum calcium remained unchanged (2.13 + or - 0.2 pre-CD, 2.14 + or - 0.2 mmol/l with CD, p = 0.74), troponin I levels were within normal parameters in both groups, concentration of phosphate was 1,56 + or - 0.43 pre-CD, 1.6 + or - 0.47 with CD (p = 0.54). iPTH levels were reduced from 342 + or - 357 to 314 + or - 375 pg/ml (p = 0.59). There was a minor decrease of serum creatinine and BUN concentrations after switching to CD (817 + or - 243 to 793 + or - 236 mu mol/l, p = 0.48 and 27.2 + or - 7.2 to 26.7 + or - 6.9 mmol/l, p = 0.62), while the levels of potassium in creased (5.44 + or - 0.89 to 5.65 + or - 0.95 mmol/l, p = 0.119). Conclusions: Data suggest that the substitution of citrate for acetate in dialysis fluids may improve acid-base status and level of inflammation in maintenance hemodialysis patients.</abstract><doi>10.5301/ijao.5000347</doi><tpages>1</tpages></addata></record>
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source Sage Journals Online
subjects Acetates
Bicarbonates
Calcium
Citrates
Citric acid
Dialysis
Patients
Switching
title THE USE OF CITRIC ACID DIALYSATE IN OUR DIALYSIS CENTER: PRELIMINARY EXPERIENCE
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