Renal Denervation: a Field in Flux

SYMPLICITY HTN-3 was a pivotal moment for renal denervation as a treatment option for resistant hypertension. Prior unblinded studies were called into question given the negative results of the first sham-controlled trial of renal denervation. Reevaluation of the renal denervation procedure demonstr...

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Bibliographic Details
Published in:Current hypertension reports 2016-07, Vol.18 (7), p.56-56, Article 56
Main Authors: Laffin, Luke J., Bakris, George L.
Format: Article
Language:English
Subjects:
Cardiology
Denervation - methods
Family Medicine
General Practice
Guidelines/Clinical Trials/Meta-Analysis (J Kostis
Humans
Hyperkalemia - drug therapy
Hypertension
Hypertension, Renal - physiopathology
Internal Medicine
Kidney - physiopathology
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Primary Care Medicine
Renin-Angiotensin System - drug effects
Section Editor
Sodium - therapeutic use
Topical Collection on Guidelines/Clinical Trials/Meta-Analysis
Zirconium - therapeutic use
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Summary:SYMPLICITY HTN-3 was a pivotal moment for renal denervation as a treatment option for resistant hypertension. Prior unblinded studies were called into question given the negative results of the first sham-controlled trial of renal denervation. Reevaluation of the renal denervation procedure demonstrated that a more precise approach was needed to adequately denervate the kidney. This new approach has been implemented in two ongoing clinical trials, one on and one off medications to assess the new procedure’s efficacy and safety. These and other ongoing trials will be discussed in the context of older studies in this field. We focus on novel findings published following the release of SYMPLICITY HTN-3 data in early 2014 and look to the future of renal denervation in the treatment of primary hypertension.
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-016-0666-1