Cardioprotective Effect of Anisodamine Against Myocardial Ischemia Injury and its Influence on Cardiomyocytes Apoptosis

Anisodamine is an ancient Chinese medicine derived from Tibet as a belladonna alkaloid, which is usually used for improvement of blood circulation in patients with organ phosphorus poisoning or shock. In this study, for the first time, we report its cardioprotective effects on preventing ischemia/re...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2015-12, Vol.73 (3), p.707-716
Main Authors: Xing, Kun, Fu, Xianghua, Jiang, Lingling, Wang, Yanbo, Li, Wei, Gu, Xinshun, Hao, Guozhen, Miao, Qing, Ge, Xiaolin, Peng, Yuhong, Geng, Wei, Bai, Shiru, Wei, Liye, Bi, Xile
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Apoptosis
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cardiotonic Agents - pharmacology
Cardiotonic Agents - therapeutic use
Cell Biology
Cell Line
Cells, Cultured
Female
Herbal medicine
Humans
Life Sciences
Male
Middle Aged
Myocardial infarction
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - etiology
Myocardial Reperfusion Injury - prevention & control
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Original Paper
Percutaneous Coronary Intervention - adverse effects
Pharmacology/Toxicology
Rats
Rats, Sprague-Dawley
Solanaceous Alkaloids - pharmacology
Solanaceous Alkaloids - therapeutic use
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Summary:Anisodamine is an ancient Chinese medicine derived from Tibet as a belladonna alkaloid, which is usually used for improvement of blood circulation in patients with organ phosphorus poisoning or shock. In this study, for the first time, we report its cardioprotective effects on preventing ischemia/reperfusion (I/R) injury of patients with acute myocardial infarction (AMI), and decreasing the myocardial infarction area and severity in heart of Sprague–Dawley (SD) rats. Our results suggest a potential molecular mechanism of anisodamine against the I/R injury in cardiomyocytes is associated with its anti-apoptotic effect. Anisodamine treatment decreases the expression of caspase-3 and caspase-8, and increases Bcl-2/Bax ratio in cardiomyocytes. Our data suggest that anisodamine can provide significant cardioprotection against I/R injury, potentially through the suppression of cardiomyocytes apoptosis.
ISSN:1085-9195
1559-0283
DOI:10.1007/s12013-015-0642-4