C–O/C–H Coupling of Polyfluoroarenes with Aryl Carbamates by Cooperative Ni/Cu Catalysis

Cross-coupling of polyfluoroarenes with aryl carbamates through the cleavage of both sp2 C–O and C–H bonds is reported. The reaction conditions are simple, and only transition-metal catalysts and ligands are essential. Mechanistic studies indicated that Ni catalyst played an important role in activa...

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Bibliographic Details
Published in:Organic letters 2016-06, Vol.18 (11), p.2548-2551
Main Authors: Wang, Yang, Wu, Song-Bai, Shi, Wen-Juan, Shi, Zhang-Jie
Format: Article
Language:English
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Summary:Cross-coupling of polyfluoroarenes with aryl carbamates through the cleavage of both sp2 C–O and C–H bonds is reported. The reaction conditions are simple, and only transition-metal catalysts and ligands are essential. Mechanistic studies indicated that Ni catalyst played an important role in activating C–O bond, while the Cu one in activating C–H Bond. The developed system proved to be effective for cross-coupling of terminal alkynes with aryl carbamates.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b00819