tert-Butyl Nitrite: Organic Redox Cocatalyst for Aerobic Aldehyde-Selective Wacker–Tsuji Oxidation

An aldehyde-selective aerobic Wacker–Tsuji oxidation is developed. Using tert-butyl nitrite as a simple organic redox cocatalyst instead of copper or silver salts, a variety of aldehydes were achieved as major products in up to 30/1 regioselectivity as well as good to high yields at room temperature...

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Bibliographic Details
Published in:Organic letters 2016-06, Vol.18 (11), p.2700-2703
Main Authors: Ning, Xiao-Shan, Wang, Mei-Mei, Yao, Chuan-Zhi, Chen, Xian-Min, Kang, Yan-Biao
Format: Article
Language:English
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Summary:An aldehyde-selective aerobic Wacker–Tsuji oxidation is developed. Using tert-butyl nitrite as a simple organic redox cocatalyst instead of copper or silver salts, a variety of aldehydes were achieved as major products in up to 30/1 regioselectivity as well as good to high yields at room temperature.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01165