A pilot study of the utility of choline PET-CT in prostate cancer biochemical relapse following radical prostatectomy

• Published in: Journal of medical imaging and radiation oncology 2016-06, Vol.60 (3), p.374-381
• Main Authors: Tan, Hendrick, Joseph, David, Loh, Nelson K, McCarthy, Michael, Leong, Eugene, Siew, Teck, Segard, Tatiana, Morandeau, Laurence, Trevenen, Michelle, Francis, Roslyn J
• Format: Article
• Language: English
• Subjects: biochemical relapse; Choline; fluorocholine PET-CT; Humans; Longitudinal Studies; Male; Neoplasm Recurrence, Local - blood; Neoplasm Recurrence, Local - diagnostic imaging; Pilot Projects; Positron Emission Tomography Computed Tomography; post-radical prostatectomy; prostate cancer; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - surgery
• ISSN: 1754-9477; 1754-9485
• DOI: 10.1111/1754-9485.12455

Introduction To evaluate the detection rate of positive choline PET–CT and its clinical role in assisting with management decisions and the correlation between positive choline PET–CT and clinical/pathological parameters in prostate cancer patients with biochemical relapse following radical prostatectomy. Methods This was a longitudinal observational pilot study of 34 patients who received choline PET–CT scans with biochemical relapse after radical prostatectomy. Variables including peak PSA, PSA doubling time (DT), Gleason score, age, initial PSA at diagnosis, use of ADT prior to PET and initial clinical staging were statistically analysed to assess for independent predictive factors for positive PET findings. Results Choline PET–CT was positive in 38.2% of patients (13/34). The only statistically significant predictor for positive PET–CT was the use of ADT prior to PET–CT, with OR 18.7 (95% CI, 2.87–122.45), P