Cross-Coupling of Acrylamides and Maleimides under Rhodium Catalysis: Controlled Olefin Migration

The rhodium­(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substitue...

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Bibliographic Details
Published in:Organic letters 2016-06, Vol.18 (11), p.2568-2571
Main Authors: Sharma, Satyasheel, Han, Sang Hoon, Oh, Yongguk, Mishra, Neeraj Kumar, Lee, Suk Hun, Oh, Joa Sub, Kim, In Su
Format: Article
Language:English
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Summary:The rhodium­(III)-catalyzed direct cross-coupling reaction of electron-deficient acrylamides with maleimides is described. This protocol displays broad functional group tolerance and high efficiency, which offers a new opportunity to access highly substituted succinimides. Dependent on the substituent positions of acrylamides and reaction conditions, olefin migrated products were obtained with high regio- and stereoselectivity.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b00909