Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes?

Serum thyroid stimulating hormone (TSH) levels increase with age. This elevation has been associated with better outcomes in very elderly subjects; however, little is known about the relationship between TSH below the lower limit of the reference range and health-related outcomes. Here, we investiga...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2016, Vol.63(5), pp.495-505
Main Authors: Dhiãnah Santini de Oliveira Chachamovitz, Vigário, Patrícia dos Santos, Silva, Silvana Oliveira e, Letícia B. B. de Mello Teixeira, Fagundes, Michele Lopes, Vaisman, Mário, Patrícia de F. dos S. Teixeira
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - blood
Cognition
Cognition - drug effects
Cognition Disorders - blood
Cognition Disorders - drug therapy
Cross-Sectional Studies
Depression
Depression - blood
Elderly
Female
Geriatric Assessment
Humans
Longitudinal Studies
Male
Methimazole - therapeutic use
Pilot Projects
Reference Values
Thyroid Function Tests - standards
Thyrotropin - blood
TSH
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Summary:Serum thyroid stimulating hormone (TSH) levels increase with age. This elevation has been associated with better outcomes in very elderly subjects; however, little is known about the relationship between TSH below the lower limit of the reference range and health-related outcomes. Here, we investigated the association between cognitive impairment or depressive symptoms and low-normal serum TSH (
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ15-0458