Autoxidative C(sp 2)–P Formation: Direct Phosphorylation of Heteroarenes under Oxygen, Metal-Free, and Solvent-Free Conditions

We reveal here a direct autoxidative phosphorylation of heteroarenes induced by oxygen under metal-free and solvent-free conditions. This new methodology provides an economical, operationally simple, and environmentally friendly approach toward (Het)­C­(sp 2)–P formation with medium to excellent yie...

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Bibliographic Details
Published in:Journal of organic chemistry 2016-06, Vol.81 (11), p.4682-4689
Main Authors: Luo, Kai, Chen, Yao-Zhong, Chen, Li-Xian, Wu, Lei
Format: Article
Language:English
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Summary:We reveal here a direct autoxidative phosphorylation of heteroarenes induced by oxygen under metal-free and solvent-free conditions. This new methodology provides an economical, operationally simple, and environmentally friendly approach toward (Het)­C­(sp 2)–P formation with medium to excellent yields. Heteroarenes including thiazole and quinoxaline derivatives are applicable under standard conditions, which is testified via a radical mechanism.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.6b00592