S100A11 is a potential prognostic marker for clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expressi...

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Bibliographic Details
Published in:Clinical & experimental metastasis 2016-01, Vol.33 (1), p.63-71
Main Authors: Gabril, Manal, Girgis, Hala, Scorilas, Andreas, Rotondo, Fabio, Wala, Samantha, Bjarnason, Georg A., Ding, Qiang, Evans, Andrew, Tawedrous, Eriny, Pasic, Maria, Finelli, Antonio, Al-Haddad, Sahar, Yousef, George M.
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - analysis
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Disease-Free Survival
Female
Hematology
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Male
Middle Aged
Oncology
Prognosis
Proportional Hazards Models
Research Paper
S100 Proteins - analysis
S100 Proteins - biosynthesis
Surgical Oncology
Tissue Array Analysis
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Summary:Clear cell renal cell carcinoma (ccRCC) is one of few cancers with rising incidence in North America. The prognosis of ccRCC is variable and difficult to predict. Stratification of patients according to disease aggressiveness can significantly improve patient management. We investigated the expression of the S100A11 protein in 385 patients with primary ccRCC using immunohistochemistry on tissue microarrays. We compared its expression with clinicopathologic parameters and patients’ survival. We also validated our results at the mRNA level on an independent set from The Cancer Genome Atlas. As a dichotomous variable (low vs. high expression), there was a significant association between S100A11 expression and tumor grade, with higher expression associated with higher tumor grades (p 
ISSN:0262-0898
1573-7276
DOI:10.1007/s10585-015-9758-6