Donor-derived tuberculosis after solid organ transplantation in two patients and a staff member

Because of global mobility and migration resulting in a growing diversity of the donor pool, the risk for donor-derived tuberculosis in solid organ transplant recipients becomes more and more relevant, even in countries with a low overall tuberculosis incidence. Here, we describe a case series of do...

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Bibliographic Details
Published in:Infection 2016-06, Vol.44 (3), p.365-370
Main Authors: Bucher, J. N., Schoenberg, M. B., Freytag, I., Lange, U., Hofmann-Thiel, S., Guba, M. O., Werner, J., Eder, A., Schelling, G., Stangl, M.
Format: Article
Language:English
Subjects:
Aged
Antitubercular Agents - administration & dosage
Antitubercular Agents - therapeutic use
Case Report
Family Medicine
Female
General Practice
Health Personnel
Humans
Infectious Diseases
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Organ Transplantation - adverse effects
Tissue Donors
Transplant Recipients
Transplants - microbiology
Tuberculosis
Tuberculosis - drug therapy
Tuberculosis - microbiology
Tuberculosis - transmission
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Summary:Because of global mobility and migration resulting in a growing diversity of the donor pool, the risk for donor-derived tuberculosis in solid organ transplant recipients becomes more and more relevant, even in countries with a low overall tuberculosis incidence. Here, we describe a case series of donor-derived tuberculosis in 2 of 3 solid organ transplant recipients and one medical staff member in Germany resulting in the death of one recipient. This case series highlights the relevance of this topic to clinicians. It advocates for a better communication between organ procurement organizations and transplant centers regarding donor information and transplant recipient outcome. Furthermore, it underpins the necessity for a standardized critical incident reporting system in the german transplant system to improve short- and long-term recipient’s safety, health and survival.
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-015-0853-z