Participation of oleic acid in the formation of the aortic aneurysm in Marfan syndrome patients

• Published in: Prostaglandins & other lipid mediators 2016-03, Vol.123, p.46-55
• Main Authors: Soto, María Elena, Iturriaga Hernández, Alejandra Valeria, Guarner Lans, Verónica, Zuñiga-Muñoz, Alejandra, Aranda Fraustro, Alberto, Velázquez Espejel, Rodrigo, Pérez-Torres, Israel
• Format: Article
• Language: English
• Subjects: Adult; Aneurysm; Aorta - metabolism; Aorta - pathology; Aorta - surgery; Aortic Aneurysm - metabolism; Aortic Aneurysm - pathology; Aortic Aneurysm - surgery; Arachidonic Acid - metabolism; Case-Control Studies; Cholesterol, HDL - metabolism; Citrulline - metabolism; Collagen - genetics; Collagen - metabolism; Fatty acids; Female; Gene Expression Regulation; Humans; Inducible nitric oxide synthase; Male; Marfan syndrome; Marfan Syndrome - metabolism; Marfan Syndrome - pathology; Marfan Syndrome - surgery; Middle Aged; Nitrates - metabolism; Nitric oxide; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type II - metabolism; Nitric Oxide Synthase Type III - genetics; Nitric Oxide Synthase Type III - metabolism; Nitrites - metabolism; Oleic acid; Oleic Acid - metabolism; Prospective Studies; Signal Transduction; Stearoyl-CoA Desaturase - genetics; Stearoyl-CoA Desaturase - metabolism; Transforming Growth Factor beta1 - genetics; Transforming Growth Factor beta1 - metabolism; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 1098-8823
• DOI: 10.1016/j.prostaglandins.2016.05.001

[Display omitted] •Marfan syndrome is associated with progressive aortic dilatation and alteration of iNOS that contribute to aneurysm formation.•An increase in oleic acid could increase iNOS and thus participate in the mechanisms that promote the aneurysms formation.•Participation of fatty acids in the mechanisms involved in the formation from aneurysm in Marfan syndrome. Marfan syndrome (MFS) is associated with progressive aortic dilatation and endothelial dysfunction that lead to early acute dissection and rupture of the aorta and sudden death. Alteration in fatty acid (FA) metabolism can stimulate nitric oxide (NO) overproduction which increases the activity of the inducible form of NO synthase (iNOS) that is involved in endothelial dysfunction. We evaluated the participation of FA in the formation of thoracic aneurysms in MFS and its relation to the iNOS. Oleic acid (OA), iNOS, citrulline, nitrates and nitrites, TGF-β1, TNF-α, monounsaturated FA and NO synthase activity were significantly increased (p