Alteration in serum klotho levels in anorexia nervosa patients

• Published in: Clinical nutrition (Edinburgh, Scotland) Scotland), 2016-08, Vol.35 (4), p.958-962
• Main Authors: Wolf, Ido, Stein, Daniel, Shahmoon, Shiri, Ziv, Shimrit Ilana, Hemi, Rina, Kanety, Hannah, Rubinek, Tami, Modan-Moses, Dalit
• Format: Article
• Language: English
• Subjects: Adipocytes; Adolescent; Alkaline Phosphatase - blood; Anorexia nervosa; Anorexia Nervosa - blood; Biomarkers - blood; Body Mass Index; Bone Density; Calcium - blood; Child; Female; Gastroenterology and Hepatology; Humans; IGF-1; Insulin-Like Growth Factor I - metabolism; Israel; Klotho; Malnutrition; Membrane Proteins - blood; Osteoporosis; Phosphorus - blood
• ISSN: 0261-5614; 1532-1983
• DOI: 10.1016/j.clnu.2015.07.013

Summary Background & aims Klotho is a trans-membrane protein which can be shed to act as a hormone; its blood levels may be regulated by the GH/IGF-1 axis. Klotho deficient mice exhibit short lifespan and characteristics of aging and malnutrition, including decreased fat and muscle mass, osteopenia, and impaired fertility. As anorexia nervosa (AN) is characterized by malnutrition and GH resistance, we hypothesized klotho levels would be altered in AN, and aimed to assess klotho levels in undernourished AN patients and changes in klotho following weight rehabilitation. Participants and methods 19 adolescent female AN inpatients (aged 16.1 ± 1.8 years) admitted to an inpatient service for eating disorders in a tertiary center were recruited. Blood samples were obtained on admission and after weight restoration (interval 4.0 ± 2.3 months) and analyzed for klotho, IGF-1, calcium, phosphorus, and alkaline phosphatase. Results Klotho levels on admission were lower than expected for age, and correlated with lumbar spine BMD Z-score ( r  = −0.81, p