Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8–deficient patients

• Published in: Journal of allergy and clinical immunology 2016-06, Vol.137 (6), p.1895-1898.e5
• Main Authors: Happel, Corinne S., MD, Stone, Kelly D., MD, PhD, Freeman, Alexandra F., MD, Shah, Nirali N., MD, Wang, Angela, BSN, Lyons, Jonathan J., MD, Guerrerio, Pamela A., MD, PhD, Hickstein, Dennis D., MD, Su, Helen C., MD, PhD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Allergy and Immunology; Allografts; Bone marrow; Child; Child, Preschool; Eggs; Female; Food; Food allergies; Food Hypersensitivity - etiology; Food Hypersensitivity - immunology; Guanine Nucleotide Exchange Factors - deficiency; Hematopoietic Stem Cell Transplantation; Humans; Male; Patients; Peanuts; Severe Combined Immunodeficiency - genetics; Severe Combined Immunodeficiency - immunology; Severe Combined Immunodeficiency - therapy; Stem cells; Transplantation Conditioning
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2015.11.017

Patient 7 also had a history of anaphylaxis to walnut as recently as 3 years before HSCT. Because of persisting positive skin prick tests, he continued to strictly avoid tree nuts after transplantation. Food-specific IgE levels also remained high for months after transplantation in several patients, even at levels having greater than a 95% positive predictive value for clinical food reactivity for some (see Table E2 in this article's Online Repository at www.jacionline.org). [...]skin prick testing revealed persisting mast cell reactivity to food allergens, which seemed to correlate best with the anaphylactic episode described after transplantation in patient 9 (see Table E1).