Ischemia-modified albumin, brain natriuretic peptide, and growth differentiation factor-15 levels in patients with nasal polyps

Abstract Objective Nasal polyps (NP) are a chronic inflammatory disease of the nasal mucosa; their etiology is suspected to involve oxidative stress. Growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and ischemia-modified albumin (IMA) are biomarkers used especially in the...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2016-10, Vol.43 (5), p.529-536
Main Authors: Sari, Kamran, Gencer, Zeliha Kapusuz, Ede, Huseyin, Gocmen, Ayse Yesim, Kantekin, Yunus
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biomarkers - blood
Brain natriuretic peptide
Case-Control Studies
Chronic inflammation
Female
Growth Differentiation Factor 15 - blood
Growth differentiation factor-15
Humans
Inflammation
Ischemia modified albumin
Male
Middle Aged
Nasal polyp
Nasal Polyps - blood
Natriuretic Peptide, Brain - blood
Otolaryngology
Oxidative Stress
Prospective Studies
Serum Albumin
Serum Albumin, Human
Young Adult
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Summary:Abstract Objective Nasal polyps (NP) are a chronic inflammatory disease of the nasal mucosa; their etiology is suspected to involve oxidative stress. Growth differentiation factor-15 (GDF-15), brain natriuretic peptide (BNP), and ischemia-modified albumin (IMA) are biomarkers used especially in the early diagnosis and follow-up of cardiovascular diseases. The aim of this study was to assess levels of serum GDF-15, BNP, and IMA in patients with NP and to compare them with those of healthy subjects. Methods This was a prospective study enrolling 41 patients with NP and 48 healthy controls, all aged 18–65 years and referred to the Department of Otorhinolaryngology, Head and Neck Surgery, between January 2014 and February 2015. After a 12-h fast, venous blood (3 mL) was drawn and centrifuged (3000 rpm, 10 min) to collect serum. Blood samples were drawn before endoscopic sinus surgery in the NP group. Serum GDF-15, BNP, and IMA levels were measured. Results GDF-15, BNP, and IMA levels of patients with NP were statistically significantly higher than in controls and GDF-15 values were higher than the normal upper limit. GDF-15, BNP, and IMA levels were significantly correlated in both groups. Conclusions As GDF-15 is a marker of chronic inflammation and oxidative stress, our finding of increased serum GDF-15 in patients with NP supports the hypothesis that its pathogenesis involves chronic inflammation and oxidative stress.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2015.12.009