Old and new applications of non-anticoagulant heparin

Abstract The aim of this chapter is to provide an overview of non-anticoagulant effects of heparins and their potential use in new therapeutic applications. Heparin and heparin derivatives have been tested in inflammatory, pulmonary and reproductive diseases, in cardiovascular, nephro- and neuro-tis...

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Bibliographic Details
Published in:International journal of cardiology 2016-06, Vol.212, p.S14-S21
Main Authors: Cassinelli, Giuseppe, Naggi, Annamaria
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antimalarials - pharmacology
Antimalarials - therapeutic use
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Cancer
Cardiovascular
Clinical Trials as Topic
Drug Repositioning
Heparin - chemistry
Heparin - pharmacology
Heparin - therapeutic use
Heparin, Low-Molecular-Weight - pharmacology
Heparin, Low-Molecular-Weight - therapeutic use
Heparins
Humans
Inflammation
Neuroprotection
Non-anticoagulant
Signal Transduction - drug effects
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Summary:Abstract The aim of this chapter is to provide an overview of non-anticoagulant effects of heparins and their potential use in new therapeutic applications. Heparin and heparin derivatives have been tested in inflammatory, pulmonary and reproductive diseases, in cardiovascular, nephro- and neuro-tissue protection and repair, but also as agents against angiogenesis, atheroschlerosis, metastasis, protozoa and viruses. Targeting and inhibition of specific mediators involved in the inflammatory process, promoting some of the above mentioned pathologies, are reported along with recent studies of heparin conjugates and oral delivery systems. Some reports from the institute of the authors, such as those devoted to glycol-split heparins are also included. Among the members and derivatives of this class, several are undergoing clinical trials as antimetastatic and antimalarial agents and for the treatment of labour pain and severe hereditary anaemia. Other heparins, whose therapeutic targets are non-anticoagulant such as nephropathies, retinopathies and cystic fibrosis are also under investigation.
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(16)12004-2