Circulating microRNAs and hypertension — from new insights into blood pressure regulation to biomarkers of cardiovascular risk

Highlights • MicroRNAs have highlighted new regulatory aspects of blood pressure control. • Array-based studies identified many microRNAs that are dysregulated in hypertension. • Circulating microRNAs are excellent candidate biomarkers in hypertension. • MicroRNA biomarkers of target-organ damage sh...

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Bibliographic Details
Published in:Current opinion in pharmacology 2016-04, Vol.27, p.1-7
Main Authors: Romaine, Simon PR, Charchar, Fadi J, Samani, Nilesh J, Tomaszewski, Maciej
Format: Article
Language:English
Subjects:
Animals
Biomarkers - blood
Blood Pressure - physiology
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cardiovascular System - physiopathology
Humans
Hypertension - blood
Hypertension - physiopathology
Internal Medicine
Medical Education
MicroRNAs - blood
Risk Factors
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Summary:Highlights • MicroRNAs have highlighted new regulatory aspects of blood pressure control. • Array-based studies identified many microRNAs that are dysregulated in hypertension. • Circulating microRNAs are excellent candidate biomarkers in hypertension. • MicroRNA biomarkers of target-organ damage show the greatest potential. • Technical challenges remain before microRNA biomarkers can enter clinical practice.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2015.12.002