Minimum absolute lymphocyte count during radiotherapy as a new prognostic factor for nasopharyngeal cancer

Background The purpose of this study was to investigate whether the minimum absolute lymphocyte count (ALC) during radiotherapy (RT) could predict clinical outcome in patients with nasopharyngeal cancer (NPC). Methods We analyzed 70 patients with NPC including 63 patients treated with chemoradiother...

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Bibliographic Details
Published in:Head & neck 2016-04, Vol.38 (S1), p.E1061-E1067
Main Authors: Cho, Oyeon, Oh, Young-Taek, Chun, Mison, Noh, O-Kyu, Hoe, Jae-Sung, Kim, Hwanik
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Disease-Free Survival
Female
Humans
lymphocyte
Lymphocyte Count
Male
Middle Aged
minimum value
nasopharyngeal cancer
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - radiotherapy
Prognosis
radiotherapy
Retrospective Studies
Survival Rate
Young Adult
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Summary:Background The purpose of this study was to investigate whether the minimum absolute lymphocyte count (ALC) during radiotherapy (RT) could predict clinical outcome in patients with nasopharyngeal cancer (NPC). Methods We analyzed 70 patients with NPC including 63 patients treated with chemoradiotherapy and used multivariate analysis to determine whether minimum ALC affected clinical outcome. Results Patients were grouped by minimum ALC, with a cutoff of 245 cells/μL. Five‐year disease‐specific survival (DSS) and progression‐free survival (PFS) for patients with minimum ALC ≥245 versus minimum ALC
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24158