The association between platelet-to-lymphocyte ratio and inflammatory markers with the severity of aortic stenosis

Platelet-to-lymphocyte ratio (PLR) was proposed as a novel indirect marker of inflammation. We aimed to evaluate the relationship between PLR and aortic stenosis (AS). The study population included 453 patients of which 98 patients with severe AS, 206 patients with mild-to-moderate AS and 149 patien...

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Bibliographic Details
Published in:Biomarkers in medicine 2016-04, Vol.10 (4), p.367-373
Main Authors: Yayla, Ça r, Açikgöz, Sad k Kadri, Yayla, Kadriye Gayretli, Açikgöz, Eser, Canpolat, U ur, Kirba, Özgür, Öksüz, Fatih, Özcan, F rat, Akbo a, Mehmet Kadri, Topalo lu, Serkan, Aras, Dursun
Format: Article
Language:English
Subjects:
Aged
Aortic stenosis
Aortic Valve Stenosis - diagnosis
Aortic Valve Stenosis - pathology
Atherosclerosis
Blood diseases
Blood Glucose - analysis
Blood platelets
Blood Platelets - cytology
Blood Platelets - metabolism
Blood pressure
C-reactive protein
C-Reactive Protein - analysis
Calcification
Cardiovascular disease
Case-Control Studies
Cholesterol
Chronic illnesses
Creatinine
Diabetes
Echocardiography
Ejection fraction
Female
Glucose
Humans
Hypertension
Inflammation
Leukocytes (neutrophilic)
Lipids
Lipoproteins
Logistic Models
Lymphocyte Count
Lymphocytes
Lymphocytes - cytology
Lymphocytes - metabolism
Male
Middle Aged
Neutrophils
Neutrophils - cytology
Neutrophils - metabolism
Odds Ratio
Platelet Count
platelet-to-lymphocyte ratio
Platelets
Population studies
Regression analysis
Retrospective Studies
Severity of Illness Index
Statistical analysis
Stenosis
Thrombosis
Velocity
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Summary:Platelet-to-lymphocyte ratio (PLR) was proposed as a novel indirect marker of inflammation. We aimed to evaluate the relationship between PLR and aortic stenosis (AS). The study population included 453 patients of which 98 patients with severe AS, 206 patients with mild-to-moderate AS and 149 patients as control. PLR was significantly increased in parallel to the severity of AS (p < 0.001). There was significant positive correlation between PLR and maximum, and mean systolic transaortic gradient (all p < 0.001). Also, PLR was correlated with C-reactive protein and neutrophil-to-lymphocyte ratio (all p < 0.001) and PLR was independently associated with the presence of AS (p < 0.001). We found a significant relationship between PLR and AS.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2015-0016