Protective, elective lung irradiation in non-metastatic Ewing's sarcoma

Ewing's sarcoma in childhood is a disease from family of the peripheral primitive neuroectodermal tumours. For a period of 16 y (1984-2000), 34 children with Ewing's sarcoma were treated and followed in our department. Twenty-seven of these patients were without distant metastases. Complex...

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Bibliographic Details
Published in:Radiation protection dosimetry 2015-07, Vol.165 (1-4), p.492-494
Main Authors: Marinova, L, Hristozova, I, Mihaylova, I, Perenovska, P
Format: Article
Language:English
Subjects:
Adolescent
Antineoplastic Combined Chemotherapy Protocols
Child
Child, Preschool
Combined Modality Therapy
Cyclophosphamide
Dactinomycin
Disease-Free Survival
Doxorubicin
Female
Follow-Up Studies
Humans
Lung - radiation effects
Neoplasm Metastasis
Radiotherapy Dosage
Remission Induction
Sarcoma, Ewing - drug therapy
Sarcoma, Ewing - radiotherapy
Treatment Outcome
Vincristine
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Summary:Ewing's sarcoma in childhood is a disease from family of the peripheral primitive neuroectodermal tumours. For a period of 16 y (1984-2000), 34 children with Ewing's sarcoma were treated and followed in our department. Twenty-seven of these patients were without distant metastases. Complex treatment was applied to all these patients-chemotherapy VACA (vincristine, actinomycin D, cyclophosphamide, adriamycin), local radiotherapy to a total dose of 50-56 Gy +/- surgery. After, a local tumour control was achieved in 11 children with non-metastatic Ewing's sarcoma, elective whole lung irradiation to a total dose of 12-15 Gy was applied. Our experience in these 11 patients with non-metastatic Ewing's sarcoma, in whom elective lung irradiation was applied, showed significant reduction in the lung metastases, improved free of disease survival and overall survival. The achieved good treatment results necessitate extending this treatment approach through defining the risk groups of patients, suitable for elective lung radiotherapy combined with chemotherapy in non-metastatic Ewing's sarcoma.
ISSN:0144-8420
1742-3406
DOI:10.1093/rpd/ncv076