Comparing the immune responses of two genetically B-complex disparate Fayoumi chicken lines to Eimeria tenella

The present study was conducted to compare the susceptibility of congenic Fayoumi lines to Eimeria tenella infection and to assess genetic differences in Eimeria egression. Chickens were orally inoculated with 5 × 10 ⁴ sporulated E. tenella oocysts and challenged with 5 × 10 ⁶ oocysts on the 10th da...

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Bibliographic Details
Published in:British poultry science 2016-03, Vol.57 (2), p.165-171
Main Authors: Lee, S.-H., Dong, X., Lillehoj, H. S., Lamont, S. J., Suo, X., Kim, D. K., Lee, K.-W., Hong, Y. H.
Format: Article
Language:English
Subjects:
Animals
Chickens
Coccidiosis - genetics
Coccidiosis - immunology
Coccidiosis - parasitology
Coccidiosis - veterinary
Disease Susceptibility - immunology
Disease Susceptibility - parasitology
Disease Susceptibility - veterinary
Eimeria tenella
Eimeria tenella - physiology
Immunity, Innate
Lymphocytes - immunology
Lymphocytes - parasitology
Poultry Diseases - genetics
Poultry Diseases - immunology
Poultry Diseases - parasitology
Sporozoites - physiology
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Summary:The present study was conducted to compare the susceptibility of congenic Fayoumi lines to Eimeria tenella infection and to assess genetic differences in Eimeria egression. Chickens were orally inoculated with 5 × 10 ⁴ sporulated E. tenella oocysts and challenged with 5 × 10 ⁶ oocysts on the 10th day after the primary infection. The Fayoumi M5.1 line exhibited higher levels of body weight gain, less oocyst shedding and higher percentages of B and CD4 ⁺/CD8 ⁺ T cells than the M15.2 chickens. These results demonstrate that M5.1 line is more resistant to E. tenella infection than M15.2 line. Furthermore, the percentage of sporozoite egress from peripheral blood mononuclear cells (PBMCs) was higher in the M5.1 line. The results of this study suggest that enhanced resistance of Fayoumi M5.1 to E. tenella infection may involve heightened cell-mediated and adaptive immunity, resulting in reduced intracellular development of Eimeria parasites.
ISSN:1466-1799
0007-1668
1466-1799
DOI:10.1080/00071668.2016.1141172