The Neutrophil to Lymphocyte Ratio Is Related to Disease Severity and Exacerbation in Patients with Chronic Obstructive Pulmonary Disease

Objective Although chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation, the association between the neutrophil to lymphocyte ratio (NLR; an indicator of inflammation) and the clinical status of COPD has not been well studied. We hypothesized that the NLR is associa...

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Bibliographic Details
Published in:Internal Medicine 2016, Vol.55(3), pp.223-229
Main Authors: Furutate, Ryuko, Ishii, Takeo, Motegi, Takashi, Hattori, Kumiko, Kusunoki, Yuji, Gemma, Akihiko, Kida, Kozui
Format: Article
Language:English
Subjects:
Aged
BODE index
Body Mass Index
COPD
Cross-Sectional Studies
Disease Progression
Dyspnea - blood
Dyspnea - immunology
Dyspnea - physiopathology
exacerbation
Exercise Test
Exercise Tolerance
Female
Humans
inflammation
Inflammation - immunology
Japan - epidemiology
Leukocyte Count
Lymphocyte Count
Lymphocytes - metabolism
Male
neutrophil to lymphocyte ratio
Neutrophils - metabolism
Pulmonary Disease, Chronic Obstructive - blood
Pulmonary Disease, Chronic Obstructive - immunology
Pulmonary Disease, Chronic Obstructive - physiopathology
Severity of Illness Index
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Summary:Objective Although chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation, the association between the neutrophil to lymphocyte ratio (NLR; an indicator of inflammation) and the clinical status of COPD has not been well studied. We hypothesized that the NLR is associated with disease severity and exacerbation in COPD patients. Methods We performed blood testing, pulmonary function testing, chest computed tomography, a body composition analysis, and a 6-minute walk test and applied the modified Medical Research Council (MMRC) dyspnea scale for 141 stable COPD patients. In addition, we calculated the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index to evaluate the disease severity. Finally, we examined the association between the NLR and clinical parameters in stable COPD patients, and we further investigated changes in the NLR between exacerbation and the stable state. Results The NLR was positively correlated with the BODE index, extent of emphysema, and MMRC score (p
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.55.5772