Viridepyronone, a New Antifungal 6-Substituted 2H-Pyran-2-one Produced by Trichoderma viride

• Published in: Journal of agricultural and food chemistry 2003-11, Vol.51 (24), p.6957-6960
• Main Authors: Evidente, Antonio, Cabras, Annalisa, Maddau, Lucia, Serra, Salvatorica, Andolfi, Anna, Motta, Andrea
• Format: Article
• Language: English
• Subjects: antifungal properties; Biological and medical sciences; Biological control; biological control agents; chemical structure; Control; Corticium rolfsii; Fundamental and applied biological sciences. Psychology; fungal antagonists; Fungal plant pathogens; Fungicides, Industrial - isolation & purification; Fungicides, Industrial - metabolism; Fungicides, Industrial - pharmacology; heterocyclic oxygen compounds; Hypocrea rufa; Phytopathology. Animal pests. Plant and forest protection; Plant Diseases - microbiology; plant pathogenic fungi; Polyporales - drug effects; Sclerotium rolfsii; Trichoderma - metabolism; Trichoderma viride
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf034708j

A new antifungal 6-substituted 2H-pyran-2-one, named viridepyronone, has been isolated from a cultural filtrate of a strain of Trichoderma viride showing antagonistic activity in vitro toward Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridepyronone was characterized as 6-(4-oxopentyl)-2H-pyran-2-one 2 with spectroscopic methods. Bioassays showed that viridepyronone had a good antifungal activity against S. rolfsii, and its minimum inhibitory concentration (over 90% inhibition) was found to be 196 μg/mL. This is the first report of viridepyronone produced by any species of fungi. Keywords: Trichoderma viride; pyran-2-one; viridepyronone; antifungal activity; Sclerotium rolfsii; crown and stem rot; biocontrol