beta sub(2)- and beta sub(3)-Adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women

• Published in: Journal of applied physiology (1985) 2004-02, Vol.96 (2), p.526-530
• Main Authors: McCole, S D, Shuldiner, A R, Brown, MD, Moore, GE, Ferrell, R E, Wilund, K R, Huberty, A, Douglass, L W, Hagberg, J M
• Format: Article
• Language: English
• ISSN: 8750-7587
• DOI: 10.1152/japplphysiol.00498.2003

We sought to determine whether common genetic variations at the beta sub(2) ( beta sub(2)-AR, Gln27Glu) and beta sub(3) ( beta sub(3)-AR, Trp64Arg) adrenergic receptor gene loci were associated with cardiovascular (CV) hemodynamics during maximal and submaximal exercise. CV hemodynamics were assessed in 62 healthy postmenopausal women (20 sedentary, 22 physically active, and 20 endurance athletes) during treadmill exercise at 40, 60, 80, and 100% maximal O sub(2) uptake using acetylene rebreathing to quantify cardiac output. The beta sub(2)-AR genotype and habitual physical activity (PA) levels interacted to significantly associate with arteriovenous O sub(2) difference (a-vDo sub(2)) during submaximal exercise (P = 0.05), with the highest submaximal exercise a-vDo sub(2) in sedentary women homozygous for the beta sub(2)-AR Gln allele and no genotype-dependent differences in submaximal exercise a-vDo sub(2) in physically active and athletic women. The beta sub(2)-AR genotype also was independently associated with a-vDo sub(2) during submaximal (P = 0.004) and similar to 100% maximal O sub(2) uptake exercise (P = 0.006), with a 1.2-2 ml/100 ml greater a-vDo sub(2) in the Gln/Gln than in the Glu/Glu genotype women. The beta sub(3)-AR genotype, independently or interacting with habitual PA levels, was not significantly associated with any CV hemodynamic variables during submaximal or maximal exercise. Thus it appears that the beta sub(2)-AR genotype, both independently and interacting with habitual PA levels, is significantly associated with a-vDo sub(2) during exercise in postmenopausal women, whereas the beta sub(3)-AR genotype does not appear to be associated with any maximal or submaximal exercise CV hemodynamic responses in postmenopausal women.