Influence of high polyphenol beverage on stress-induced platelet activation

Objectives Platelets are playing a crucial role in acute cardiovascular events. We investigated if physical stress activates platelets and whether this activation can be inhibited by a polyphenol-enriched diet. Methods Blood samples were taken from a total of 103 athletes three weeks before, one day...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging health & aging, 2016-06, Vol.20 (6), p.586-593
Main Authors: Nickel, Thomas, Lackermair, K., Scherr, J., Calatzis, A., Vogeser, M., Hanssen, H., Waidhauser, G., Schönermark, U., Methe, H., Horster, S., Wilbert-Lampen, U., Halle, M.
Format: Article
Language:English
Subjects:
Adult
Aging
Atherosclerosis
Atherosclerosis - pathology
Beer
Blood platelets
Cardiovascular system
Exercise
Female
Flavonoids
Geriatrics/Gerontology
Hospitals
Humans
Inflammatory diseases
Internal medicine
Male
Marathons
Medicine
Medicine & Public Health
Neurosciences
Nutrition
Nutrition research
Peptides
Platelet Activation - physiology
Platelet Aggregation
Polyphenols
Polyphenols - pharmacology
Primary Care Medicine
Prospective Studies
Quality of Life Research
Sports medicine
Thrombosis
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Summary:Objectives Platelets are playing a crucial role in acute cardiovascular events. We investigated if physical stress activates platelets and whether this activation can be inhibited by a polyphenol-enriched diet. Methods Blood samples were taken from a total of 103 athletes three weeks before, one day before, immediately as well as 24 hours and 72 hours after a marathon run. Participants were randomized, double-blinded and divided into two groups. One group received a polyphenol-rich beverage the other the same beverage without polyphenols. Besides analysis of platelet counts and impedance-aggregometric-measurement of platelet activity, soluble P-selectin and Endothelin-A measurements were performed. Results In the control group, runners showed a 2.2-fold increased platelet aggregation directly after completing a marathon and within the following three days when compared with baseline values (p
ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-016-0697-y