Dipole Excitation: A New Method for Mass Analysis with a Quadrupole Mass Filter

• Published in: Journal of the American Society for Mass Spectrometry 2016-07, Vol.27 (7), p.1236-1242
• Main Authors: Konenkov, Nikolai V., Douglas, Donald J., Berdnikov, Alexander S.
• Format: Article
• Language: English
• Subjects: Analytical Chemistry; Bioinformatics; Biotechnology; Chemistry; Chemistry and Materials Science; Dipoles; Electrodes; Excitation; Ion motion; Mass spectrometry; Multipoles; Organic Chemistry; Proteomics; Quadrupoles; Research Article; Rods; Stability; Trajectory analysis
• ISSN: 1044-0305; 1879-1123
• DOI: 10.1007/s13361-016-1376-2

Trajectory calculations are used to investigate peak shapes and ion transmission with a proposed new method of mass analysis with a quadrupole mass filter. Dipole excitation is applied to either the x or the y electrodes, or both, to create bands of instability within the first stability region. With excitation between the y electrodes (near β y  = 0), ions are removed from the low mass side of a peak, and with ion excitation in x (near β x  = 1), ions are removed from the high mass side. The mass resolution can be approximately doubled with comparatively little loss in ion transmission. Ion motion in an ideal quadrupole field and in the field of a quadrupole constructed with round rods has been studied. With an ideal quadrupole field, excitation in y is found to give better peak shape and resolution than excitation in x . With quadrupoles constructed with round rods, excitation in y is found to remove ions from both the low and high mass sides of a peak. The additional higher order multipoles introduced to the quadrupole potential by the use of round rods couple the x motion to the y motion so that exciting the y motion also excites ions in x . Thus, only excitation in y is necessary. Both with an ideal quadrupole field and quadrupoles constructed with round rods, the resolution can be increased ca. ×2 with little loss of transmission. Graphical Abstract ᅟ