Bioengineered living cardiac and venous valve replacements: current status and future prospects

Abstract Valvular heart disease remains to be a major cause of death worldwide with increasing prevalence, mortality and morbidity. Current heart valve replacements are associated with several limitations due to their nonviable nature. In this regard, heart valve tissue engineering has shown to repr...

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Bibliographic Details
Published in:Cardiovascular pathology 2016-07, Vol.25 (4), p.300-305
Main Authors: Kehl, D, Weber, B, Hoerstrup, S.P
Format: Article
Language:English
Subjects:
3D printing
Animals
Electrospinning
Heart Valve Prosthesis
Heart valve tissue engineering
Heart Valves
Humans
In situ tissue engineering
In vitro tissue engineering
Pathology
Tissue Engineering - methods
Tissue Engineering - trends
Venous Valves
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Summary:Abstract Valvular heart disease remains to be a major cause of death worldwide with increasing prevalence, mortality and morbidity. Current heart valve replacements are associated with several limitations due to their nonviable nature. In this regard, heart valve tissue engineering has shown to represent a promising concept in order to overcome these limitations and replace diseased cardiac valves with living, autologous constructs. These bioengineered valves hold potential for in situ remodeling, growth and repair throughout the patient's lifetime without the risk of thromboembolic complications and adverse immune responses. For the fabrication of tissue engineered heart valves several concepts have been established, the “classical” in vitro tissue engineering approach, the in situ tissue engineering approach, and alternative approaches including 3D printing and electrospinning. Besides first attempts have been conducted in order to produce a tissue engineered venous valve for the treatment of deep venous valve insufficiency. Here we review basic principals and current scientific status of valvular tissue engineering, including a critical discussion and outlook for the future.
ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2016.03.001