Increased risk of malignancy for non-atypical urothelial cell groups compared to negative cytology in voided urine. Morphological changes with LBC

Liquid‐based cytology (LBC) has recently become the preferred method for urine cytology analysis, but differences with conventional cytology (CC) have been observed. The purpose of this study is to analyze these differences and the clinical relevance of non‐atypical urothelial cell groups (UCG) in v...

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Bibliographic Details
Published in:Diagnostic cytopathology 2016-07, Vol.44 (7), p.582-590
Main Authors: Granados, Rosario, Butrón, Mercedes, Santonja, Carlos, Rodríguez, José-María, Martín, Ana, Duarte, Joanny, Camarmo, Encarnación, Corrales, Teresa, Aramburu, José-Antonio
Format: Article
Language:English
Subjects:
Biopsy
Carcinoma - pathology
Carcinoma - urine
cell groups
Humans
increased risk
Liquid-based cytology
malignancy
Sensitivity and Specificity
Urine - cytology
Urogenital Neoplasms - pathology
Urogenital Neoplasms - urine
urothelial
Urothelium - pathology
voided urine
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Summary:Liquid‐based cytology (LBC) has recently become the preferred method for urine cytology analysis, but differences with conventional cytology (CC) have been observed. The purpose of this study is to analyze these differences and the clinical relevance of non‐atypical urothelial cell groups (UCG) in voided urine specimens. Reporting terminology is discussed. Initially, diagnostic categories from 619 LBC and 474 CC samples, reviewed by five different pathologists, were compared (phase 1). Five years after LBC was implemented and applying strict cytologic criteria for UCG diagnosis, 760 samples were analyzed (phase 2) and compared to previous LBC specimens. Diagnostic differences, interobserver variability and clinicopathological correlation with a 6‐month follow‐up, were analyzed. UCG increased from 6.5% with CC to 20.7% (218%, 3.2 fold, P 
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23489