CREB1 Genotype Modulates Adaptive Reward-Based Decisions in Humans

Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes of CREB in the nucleus accumbens (NAc) and orbital frontal cortex (OFC) interact with be...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2016-07, Vol.26 (7), p.2970-2981
Main Authors: Wolf, Claudia, Mohr, Holger, Diekhof, Esther K, Vieker, Henning, Goya-Maldonado, Roberto, Trost, Sarah, Krämer, Bernd, Keil, Maria, Binder, Elisabeth B, Gruber, Oliver
Format: Article
Language:English
Subjects:
Adaptation, Psychological - physiology
Adult
Brain - diagnostic imaging
Brain - physiology
Brain Mapping
Cerebrovascular Circulation - physiology
Cyclic AMP Response Element-Binding Protein - genetics
Decision Making - physiology
Executive Function - physiology
Female
Genotype
Genotyping Techniques
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Oxygen - blood
Polymorphism, Single Nucleotide
Reward
Young Adult
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Summary:Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes of CREB in the nucleus accumbens (NAc) and orbital frontal cortex (OFC) interact with behavioral changes during reward-motivated learning. However, these findings from animal models have not been evaluated in humans. We tested whether CREB1 genotypes affect reward-motivated decisions and related brain activation, using BOLD fMRI in 224 young and healthy participants. More specifically, participants needed to adapt their decision to either pursue or resist immediate rewards to optimize the reward outcome. We found significant CREB1 genotype effects on choices to pursue increases of the reward outcome and on BOLD signal in the NAc, OFC, insula cortex, cingulate gyrus, hippocampus, amygdala, and precuneus during these decisions in comparison with those decisions avoiding total reward loss. Our results suggest that CREB1 genotype effects in these regions could contribute to individual differences in reward- and associative memory-based decision-making.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhv104