A Differential Gene Expression Study: Ptpn6 (SHP-1)-insufficiency Leads to Neutrophilic Dermatosis-like Disease (NDLD) in Mice

Highlights • The 63 genes in the bone marrow of NDLD mice had more than a 4-fold change with FDR

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Bibliographic Details
Published in:Journal of dermatological science 2016-07, Vol.83 (1), p.17-25
Main Authors: Nesterovitch, Andrew B, Arbieva, Zarema, Toth, Daniel M, Tharp, Michael D, Glant, Tibor T
Format: Article
Language:English
Subjects:
Animals
Autoinflammatory
Bone Marrow Cells - metabolism
Cell Differentiation
Dermatology
Gene expression microarray
Gene Expression Profiling
Humans
Immunity, Innate - genetics
Interleukin-1beta - metabolism
Lectins, C-Type - metabolism
Mice
Motheaten
Mutation
Neutrophilic dermatoses
Neutrophils - immunology
Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics
Pyoderma gangrenosum
Pyoderma Gangrenosum - genetics
Pyoderma Gangrenosum - immunology
SHP-1
Signal Transduction
Skin - metabolism
Sweet Syndrome - genetics
Sweet Syndrome - immunology
Toll-Like Receptors - metabolism
Up-Regulation
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Description
Summary:Highlights • The 63 genes in the bone marrow of NDLD mice had more than a 4-fold change with FDR
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.03.005