Systemic Inflammatory Response After Open, Laparoscopic and Robotic Surgery in Endometrial Cancer Patients

To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative...

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Bibliographic Details
Published in:Anticancer research 2016-06, Vol.36 (6), p.2909-2922
Main Authors: Pilka, Radovan, Marek, Radim, Adam, Tomas, Kudela, Milan, Ondrová, Dana, Neubert, David, Hambálek, Jozef, Maděrka, Martin, Solichová, Dagmar, Krčmová, Lenka Kujovská, Melichar, Bohuslav
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
C-Reactive Protein - analysis
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - surgery
Female
Humans
Inflammation - etiology
Interleukin-6 - blood
Laparoscopy - methods
Middle Aged
Neopterin - urine
Prospective Studies
Robotic Surgical Procedures - methods
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Summary:To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma.
ISSN:1791-7530