Is there an association between systemic lupus erythematosus and periodontal disease?

Periodontal disease results from the interaction between pathogenic bacteria that colonize supragingival and subgingival biofilms and the host, triggering an inflammatory response, with systemic effects leading to immune-mediated destruction of the attachment apparatus and loss of supporting alveola...

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Bibliographic Details
Published in:Revista Brasileira de Reumatologia 2016-05, Vol.56 (3), p.280-284
Main Authors: Calderaro, Débora Cerqueira, Ferreira, Gilda Aparecida, de Mendonça, Santuza Maria Souza, Corrêa, Jôice Dias, Santos, Fabrícia Xavier, Sanção, João Guilherme Capinam, da Silva, Tarcília Aparecida, Teixeira, Antônio Lúcio
Format: Article
Language:English
Subjects:
Alveolar Bone Loss
Chronic periodontitis
Disease Progression
Gingival Diseases
Humans
Lupus Erythematosus, Systemic - epidemiology
Lúpus eritematoso sistêmico
Periodontal Attachment Loss
Periodontal Diseases - epidemiology
Periodontite
Periodontite crônica
Periodontitis
Rheumatic Diseases
Systemic lupus erythematosus
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Summary:Periodontal disease results from the interaction between pathogenic bacteria that colonize supragingival and subgingival biofilms and the host, triggering an inflammatory response, with systemic effects leading to immune-mediated destruction of the attachment apparatus and loss of supporting alveolar bone. Immunological pathways and predisposing genetic factors common to periodontal disease and rheumatic diseases, including systemic lupus erythematosus, have been described. Case reports have suggested greater severity of periodontal disease in patients with systemic lupus erythematosus. However, studies evaluating the influence of the treatment of one disease on the clinical and laboratory manifestations of the other have yielded conflicting results. A doença periodontal resulta da interação entre bactérias patogênicas que colonizam os filmes supra e subgengival e o hospedeiro e deflagram uma resposta inflamatória local, com efeitos sistêmicos, que leva à destruição imunomediada dos tecidos de sustentação dos dentes e do osso alveolar. Vias imunológicas e fatores genéticos predisponentes comuns à doença periodontal e às doenças reumáticas, entre elas o lúpus eritematoso sistêmico, vêm sendo descritos. Relatos de caso sugeriram maior gravidade da doença periodontal em pacientes com lúpus eritematoso sistêmico. No entanto, estudos que avaliaram as influências do tratamento de uma sobre as manifestações da outra apresentaram resultados conflitantes.
ISSN:2255-5021
1809-4570
2255-5021
DOI:10.1016/j.rbre.2015.08.003