Clinical Value of Squamous Cell Carcinoma Antigen (SCCAg) in Anal Cancer - A Single-Center Retrospective Analysis

To assess the clinical value of squamous cell carcinoma antigen (SCCAg) in anal cancer for chemoradiotherapy (CRT) patients. In 24 patients with SCC of the anus, SCCAg was determined before CRT and at every follow-up visit. 16/24 (66.7%) had normal SCCAg and 11/16 (68.8%) achieved complete remission...

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Bibliographic Details
Published in:Anticancer research 2016-06, Vol.36 (6), p.3173-3177
Main Authors: Henkenberens, Christoph, Toklu, Hakan, Tamme, Carsten, Bruns, Frank
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm - analysis
Anus Neoplasms - immunology
Anus Neoplasms - therapy
Chemoradiotherapy
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Retrospective Studies
Serpins - analysis
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Summary:To assess the clinical value of squamous cell carcinoma antigen (SCCAg) in anal cancer for chemoradiotherapy (CRT) patients. In 24 patients with SCC of the anus, SCCAg was determined before CRT and at every follow-up visit. 16/24 (66.7%) had normal SCCAg and 11/16 (68.8%) achieved complete remission (CR), while 7/8 (87.5%) with elevated SCCAg achieved CR. In two patients, elevated SCCAg was observed after radiotherapy. One was false-positive and one was true-positive leading to diagnosis of metachronous recurrent and metastatic disease after interim CR. SCCAg was inappropriate to predict the clinical outcome but can provide additional information on the regular follow-up examinations to detect a relapse.
ISSN:1791-7530