ABCG2 Overexpression Confers Poor Outcomes in Hepatocellular Carcinoma of Elderly Patients

Backgroung/Aim: Breast cancer resistance protein [BCRP/ATP-binding cassette subfamily G member 2 (ABCG2)] is a member of the ATP-binding cassette transporter family, used as a maker of cancer stem cells (CSCs) and thought to be responsible for drug resistance by pumping them out of cells. However, i...

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Bibliographic Details
Published in:Anticancer research 2016-06, Vol.36 (6), p.2983-2988
Main Authors: Chen, Yao-Li, Chen, Po-Ming, Lin, Ping-Yi, Hsiau, Ya-Tze, Chu, Pei-Yi
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
ATP Binding Cassette Transporter, Sub-Family G, Member 2 - analysis
Carcinoma, Hepatocellular - chemistry
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - virology
Hepatitis B virus - isolation & purification
Humans
Immunohistochemistry
Liver - chemistry
Liver Neoplasms - chemistry
Liver Neoplasms - mortality
Liver Neoplasms - virology
Middle Aged
Neoplasm Proteins - analysis
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Summary:Backgroung/Aim: Breast cancer resistance protein [BCRP/ATP-binding cassette subfamily G member 2 (ABCG2)] is a member of the ATP-binding cassette transporter family, used as a maker of cancer stem cells (CSCs) and thought to be responsible for drug resistance by pumping them out of cells. However, its precise role in various cancer types has been controversial, and the aim of this study was to investigate the expression of ABCG2 in hepacellular carcinoma (HCC) and relate the results to established prognostic factors. We conducted analysis of 181 HCC and paired-match adjacent normal liver tissue by immunohistochemistry from tissue array of slides. The mean score for ABCG2 expression was higher in tumor than in adjacent normal liver tissue of HCC patients (p
ISSN:1791-7530