Viral RNA polymerase scanning and the gymnastics of Sendai virus RNA synthesis

mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in that the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the nex...

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Bibliographic Details
Published in:Virology 2004-01, Vol.318 (2), p.463-473
Main Authors: Kolakofsky, Daniel, Le Mercier, Philippe, Iseni, Frédéric, Garcin, Dominique
Format: Article
Language:English
Subjects:
nonsegmented negative-strand RNA virus
RNA polymerase
Sendai virus
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Summary:mRNA synthesis from nonsegmented negative-strand RNA virus (NNV) genomes is unique in that the genome RNA is embedded in an N protein assembly (the nucleocapsid) and the viral RNA polymerase does not dissociate from the template after release of each mRNA, but rather scans the genome RNA for the next gene-start site. A revised model for NNV RNA synthesis is presented, in which RNA polymerase scanning plays a prominent role. Polymerase scanning of the template is known to occur as the viral transcriptase negotiates gene junctions without falling off the template.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2003.10.031