Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents

• Published in: Toxicology and applied pharmacology 2004-02, Vol.195 (1), p.1-11
• Main Authors: Schins, Roel P.F, Lightbody, Janet H, Borm, Paul J.A, Shi, Tingming, Donaldson, Ken, Stone, Vicki
• Format: Article
• Language: English
• Subjects: Air Pollutants - chemistry; Air Pollutants - toxicity; Animals; Biological and medical sciences; Bronchoalveolar Lavage Fluid - chemistry; Bronchoalveolar Lavage Fluid - cytology; Chemical and industrial products toxicology. Toxic occupational diseases; Coarse particles; Electron paramagnetic resonance; Endotoxin; Endotoxins - isolation & purification; Female; Fine particles; Germany; Glutathione - analysis; Hydroxyl Radical - isolation & purification; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.); Instillation, Drug; Interleukin-8; Interleukin-8 - blood; L-Lactate Dehydrogenase - analysis; Leukocyte Count; Lung - drug effects; Lung - metabolism; Lung inflammation; Medical sciences; Metals; Metals, Heavy - isolation & purification; Neutrophils - cytology; Particle composition; Particle Size; PM 10; PM 2.5; Pneumonia - blood; Pneumonia - metabolism; Rats; Rats, Wistar; Toxicology; Tumor necrosis factor α; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - metabolism; Whole blood
• ISSN: 0041-008X; 1096-0333
• DOI: 10.1016/j.taap.2003.10.002

There is conflicting evidence in the literature as to the predominant mechanism and also the compositional element(s) that drives the pulmonary inflammatory response of ambient particulate matter (PM). We have investigated the inflammogenic potential of coarse (2.5–10 μm) and fine (