Fungichromin:  A Substance from Streptomyces padanus with Inhibitory Effects on Rhizoctonia solani

• Published in: Journal of agricultural and food chemistry 2003-01, Vol.51 (1), p.95-99
• Main Authors: Shih, Hsin-Der, Liu, Yung-Chuan, Hsu, Fen-Lin, Mulabagal, Vanisree, Dodda, Rajasekhar, Huang, Jenn-Wen
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Brassica - microbiology; Food industries; Food microbiology; Fruit and vegetable industries; Fundamental and applied biological sciences. Psychology; Fungicides, Industrial - pharmacology; Macrolides; Molecular Structure; Polyenes - analysis; Polyenes - isolation & purification; Polyenes - pharmacokinetics; Rhizoctonia - drug effects; Rhizoctonia solani; Streptomyces - chemistry; Streptomyces padanus
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf025879b

Streptomyces padanus strain PMS-702 is an antagonist of Rhizoctonia solani AG-4, the causal agent of damping-off of cabbage. Treatment of cabbage seeds with the culture filtrate of S. padanus strain PMS-702 was effective in reducing the incidence of damping-off of cabbage. The major active ingredient from the culture filtrate of S. padanus strain PMS-702 was purified by silica gel column chromatography and identified as the polyene macrolide, fungichromin, by NMR and mass spectral data. Bioassay studies showed that fungichromin had a strong antifungal activity against R. solani AG-4, and its minimum inhibitory concentration (over 90% inhibition) was found to be 72 μg/mL. This is the first report of fungichromin from S. padanus as an active ingredient for the control of Rhizoctonia damping-off of cabbage. Keywords: Fungichromin; Streptomyces padanus; Rhizoctonia solani; biocontrol; antifungal substance; polyene macrolide