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Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease
Dry eye disease (DED) is a prevalent public health concern that affects up to 30% of adults and is particularly chronic and severe in the elderly. Two interconnected mechanisms cause DED: (1) an age-related dysfunction of lacrimal and meibomian glands, which leads to decreased tear production and/or...
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| Published in: | Ocular immunology and inflammation 2016-06, Vol.24 (3), p.327-347 |
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| cites | cdi_FETCH-LOGICAL-c497t-88a7acbd405714d75f950297b0b8b0387fc7893b7d578f68f1e1d2ce18709b3a3 |
| container_end_page | 347 |
| container_issue | 3 |
| container_start_page | 327 |
| container_title | Ocular immunology and inflammation |
| container_volume | 24 |
| creator | Farid, Marjan Agrawal, Anshu Fremgen, Daniel Tao, Jeremiah Chuyi, He Nesburn, Anthony B. BenMohamed, Lbachir |
| description | Dry eye disease (DED) is a prevalent public health concern that affects up to 30% of adults and is particularly chronic and severe in the elderly. Two interconnected mechanisms cause DED: (1) an age-related dysfunction of lacrimal and meibomian glands, which leads to decreased tear production and/or an increase in tear evaporation; and (2) an age-related uncontrolled inflammation of the surface of the eye triggered by yet-to-be-determined internal immunopathological mechanisms, independent of tear deficiency and evaporation. In this review we summarize current knowledge on animal models that mimic both the severity and chronicity of inflammatory DED and that have been reliably used to provide insights into the immunopathological mechanisms of DED, and we provide an overview of the opportunities and limitations of the rabbit model in investigating the role of both ocular and nasal mucosal immune systems in the immunopathology of inflammatory DED and in testing novel immunotherapies aimed at delaying or reversing the uncontrolled age-related inflammatory DED. |
| doi_str_mv | 10.3109/09273948.2014.986581 |
| format | article |
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Two interconnected mechanisms cause DED: (1) an age-related dysfunction of lacrimal and meibomian glands, which leads to decreased tear production and/or an increase in tear evaporation; and (2) an age-related uncontrolled inflammation of the surface of the eye triggered by yet-to-be-determined internal immunopathological mechanisms, independent of tear deficiency and evaporation. In this review we summarize current knowledge on animal models that mimic both the severity and chronicity of inflammatory DED and that have been reliably used to provide insights into the immunopathological mechanisms of DED, and we provide an overview of the opportunities and limitations of the rabbit model in investigating the role of both ocular and nasal mucosal immune systems in the immunopathology of inflammatory DED and in testing novel immunotherapies aimed at delaying or reversing the uncontrolled age-related inflammatory DED.</description><identifier>ISSN: 0927-3948</identifier><identifier>EISSN: 1744-5078</identifier><identifier>DOI: 10.3109/09273948.2014.986581</identifier><identifier>PMID: 25535823</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Aging ; Aging - physiology ; Conjunctiva - immunology ; dry eye ; Dry Eye Syndromes - immunology ; Humans ; Immune System - physiology ; inflammation ; Mucous Membrane ; Nasal Mucosa - immunology ; nasal mucosal immune system ; ocular mucosal immune system ; T-Lymphocytes, Regulatory - immunology ; Th1 ; Th1 Cells - immunology ; Th17 ; Th17 Cells - immunology ; treg</subject><ispartof>Ocular immunology and inflammation, 2016-06, Vol.24 (3), p.327-347</ispartof><rights>2016 Taylor & Francis Group, LLC 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-88a7acbd405714d75f950297b0b8b0387fc7893b7d578f68f1e1d2ce18709b3a3</citedby><cites>FETCH-LOGICAL-c497t-88a7acbd405714d75f950297b0b8b0387fc7893b7d578f68f1e1d2ce18709b3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25535823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farid, Marjan</creatorcontrib><creatorcontrib>Agrawal, Anshu</creatorcontrib><creatorcontrib>Fremgen, Daniel</creatorcontrib><creatorcontrib>Tao, Jeremiah</creatorcontrib><creatorcontrib>Chuyi, He</creatorcontrib><creatorcontrib>Nesburn, Anthony B.</creatorcontrib><creatorcontrib>BenMohamed, Lbachir</creatorcontrib><title>Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease</title><title>Ocular immunology and inflammation</title><addtitle>Ocul Immunol Inflamm</addtitle><description>Dry eye disease (DED) is a prevalent public health concern that affects up to 30% of adults and is particularly chronic and severe in the elderly. 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In this review we summarize current knowledge on animal models that mimic both the severity and chronicity of inflammatory DED and that have been reliably used to provide insights into the immunopathological mechanisms of DED, and we provide an overview of the opportunities and limitations of the rabbit model in investigating the role of both ocular and nasal mucosal immune systems in the immunopathology of inflammatory DED and in testing novel immunotherapies aimed at delaying or reversing the uncontrolled age-related inflammatory DED.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Conjunctiva - immunology</subject><subject>dry eye</subject><subject>Dry Eye Syndromes - immunology</subject><subject>Humans</subject><subject>Immune System - physiology</subject><subject>inflammation</subject><subject>Mucous Membrane</subject><subject>Nasal Mucosa - immunology</subject><subject>nasal mucosal immune system</subject><subject>ocular mucosal immune system</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th1</subject><subject>Th1 Cells - immunology</subject><subject>Th17</subject><subject>Th17 Cells - immunology</subject><subject>treg</subject><issn>0927-3948</issn><issn>1744-5078</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkU1v1DAQhi1ERZfCP0DIRy5Z7Nhe2xdQ1S1tpX4cgLPlOOPdICde7KQo_56EtBW9wGkkzzPv2H4QekfJmlGiPxJdSqa5WpeE8rVWG6HoC7SikvNCEKleotWMFDNzjF7n_IMQwrWmr9BxKQQTqmQrtD_dQZEg2B5qvAUPrs-46fCdG4JN2HY1vrXZBnwzuDjXq7YdOsBfx9xD-6ff72E5jQfb72OIuxFHj7dpxOcj4G2TwWZ4g468DRnePtQT9P3L-bezy-L67uLq7PS6cFzLvlDKSuuqmhMhKa-l8FqQUsuKVKoiTEnvpNKskrWQym-Up0Dr0gFVkuiKWXaCPi25h6FqoXbQ9ckGc0hNa9Noom3M807X7M0u3hvOpSoVnwI-PASk-HOA3Ju2yQ5CsB3EIRuqyLSL6A35Pyq1nL5aMjWhfEFdijkn8E83osTMPs2jTzP7NIvPaez93695GnoUOAGfF6DpfEyt_RVTqE1vxxCTT7ZzTZ7j_7HiN-jQr44</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Farid, Marjan</creator><creator>Agrawal, Anshu</creator><creator>Fremgen, Daniel</creator><creator>Tao, Jeremiah</creator><creator>Chuyi, He</creator><creator>Nesburn, Anthony B.</creator><creator>BenMohamed, Lbachir</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>201606</creationdate><title>Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease</title><author>Farid, Marjan ; 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In this review we summarize current knowledge on animal models that mimic both the severity and chronicity of inflammatory DED and that have been reliably used to provide insights into the immunopathological mechanisms of DED, and we provide an overview of the opportunities and limitations of the rabbit model in investigating the role of both ocular and nasal mucosal immune systems in the immunopathology of inflammatory DED and in testing novel immunotherapies aimed at delaying or reversing the uncontrolled age-related inflammatory DED.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>25535823</pmid><doi>10.3109/09273948.2014.986581</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0927-3948 |
| ispartof | Ocular immunology and inflammation, 2016-06, Vol.24 (3), p.327-347 |
| issn | 0927-3948 1744-5078 |
| language | eng |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aging Aging - physiology Conjunctiva - immunology dry eye Dry Eye Syndromes - immunology Humans Immune System - physiology inflammation Mucous Membrane Nasal Mucosa - immunology nasal mucosal immune system ocular mucosal immune system T-Lymphocytes, Regulatory - immunology Th1 Th1 Cells - immunology Th17 Th17 Cells - immunology treg |
| title | Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease |
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