Novel herpesviruses of Suidae: indicators for a second genogroup of artiodactyl gammaherpesviruses

1 P11/Neuartige Viren, Robert Koch-Institut, Nordufer 20, D-13353 Berlin, Germany 2 Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK Correspondence Bernhard Ehlers ehlersb{at}rki.de Five novel herpesviruses were id...

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Bibliographic Details
Published in:Journal of general virology 2004-04, Vol.85 (4), p.857-862
Main Authors: Ehlers, B, Lowden, S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Artiodactyla - virology
Biological and medical sciences
DNA-Directed DNA Polymerase - genetics
Fundamental and applied biological sciences. Psychology
Gammaherpesvirinae - classification
Gammaherpesvirinae - enzymology
Gammaherpesvirinae - genetics
Herpesviridae Infections - transmission
Herpesviridae Infections - veterinary
Herpesvirus
Humans
Microbiology
Miscellaneous
Molecular Sequence Data
Phylogeny
Sequence Homology, Amino Acid
Species Specificity
Suidae
Sus scrofa - virology
Swine - virology
Transplantation, Heterologous - adverse effects
Virology
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Summary:1 P11/Neuartige Viren, Robert Koch-Institut, Nordufer 20, D-13353 Berlin, Germany 2 Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK Correspondence Bernhard Ehlers ehlersb{at}rki.de Five novel herpesviruses were identified in suid species from Africa (common warthog, Phacochoerus africanus ) and South-East Asia (bearded pig, Sus barbatus ; babirusa, Babyrousa babyrussa ) by detection and analysis of their DNA polymerase genes. Three of the novel species, P. africanus cytomegalovirus 1, P. africanus lymphotropic herpesvirus 1 (PafrLHV-1) and S. barbatus lymphotropic herpesvirus 1 (SbarLHV-1), were closely related to known beta- (porcine cytomegalovirus) and gammaherpesviruses [porcine lymphotropic herpesvirus (PLHV) 1 and 3] of domestic pigs. In contrast, two novel species, S. barbatus rhadinovirus 1 (SbarRHV-1) and Babyrousa babyrussa rhadinovirus 1 (BbabRHV-1), were more closely related to a ruminant gammaherpesvirus, bovine herpesvirus 4 (BoHV-4), than to the porcine gammaherpesviruses PLHV-1, -2, -3, PafrLHV-1 and SbarLHV-1. SbarRHV-1, BbabRHV-1 and BoHV-4 were therefore tentatively assigned to a novel genogroup of artiodactyl gammaherpesviruses. This latter genogroup may also contain an as yet undiscovered gammaherpesvirus of domestic pigs, thereby adding a concern to their use in xenotransplantation.
ISSN:0022-1317
1465-2099
DOI:10.1099/vir.0.79799-0