A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent

Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a diox...

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Published in:Journal of inorganic biochemistry 2016-06, Vol.159, p.1-6
Main Authors: Xu, Xiao-Lei, Shao, Jian, Chen, Qiu-Yun, Li, Cheng-Hao, Kong, Meng-Yun, Fang, Fang, Ji, Ling, Boison, Daniel, Huang, Tao, Gao, Jing, Feng, Chang-Jian
Format: Article
Language:English
Subjects:
Antineoplastic Agents
Boron Compounds - chemistry
Boron Compounds - pharmacology
Cancer
Cobalt - chemistry
Cobalt - pharmacology
Drug Screening Assays, Antitumor
Graphene
Graphite - chemistry
Graphite - pharmacology
H2O2-activatable
Hep G2 Cells
Humans
Hydrogen Peroxide - pharmacology
Light
Manganese
Photodynamic
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Summary:Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn1 and its loaded graphene oxide (herein called Mn1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments. Photoactive Mn(II) complex loaded GO (Mn1@GO) shows both LED light and H2O2-activated enhanced inhibition on the proliferation of HepG-2 cells in hypoxic conditions. [Display omitted] •A manganese complex (Mn1)/water system as a dioxygen generator•Electrochemical properties of Mn1 and its loaded graphene oxide (Mn1@GO) were reported.•Mn1@GO can react with H2O2 resulting active anticancer species.•Mn1@GO was used as materials for hypoxic cancer phototherapy.•The mechanism of LED light enhanced anticancer activity was discussed.
ISSN:0162-0134
1873-3344
DOI:10.1016/j.jinorgbio.2016.02.007