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Desmethylanhydroicaritin isolated from Sophora flavescens , shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion
Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for trea...
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Published in: | Environmental toxicology and pharmacology 2016-04, Vol.43, p.140-148 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for treating human glioblastoma. |
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ISSN: | 1382-6689 1872-7077 |
DOI: | 10.1016/j.etap.2016.03.003 |