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Desmethylanhydroicaritin isolated from Sophora flavescens , shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for trea...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2016-04, Vol.43, p.140-148
Main Authors: Kang, Chang-Won, Kim, Nan-Hee, Jung, Huyn Ah, Choi, Hyung-Wook, Kang, Min-Jae, Choi, Jae-Sue, Kim, Gun-Do
Format: Article
Language:English
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Summary:Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for treating human glioblastoma.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.03.003