Plasma Phthalate and Bisphenol A Levels and Oxidant-Antioxidant Status in Autistic Children

Highlights • Plasma phthalate and bisphenol A (BPA) levels were determined in autistic children. • Oxidant/antioxidant status was also evaluated. • Plasma BPA levels of children with PDD-NOS were significantly higher than control. • BPA exposure might be associated with PDD-NOS and oxidative stress....

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2016-04, Vol.43, p.149-158
Main Authors: Kondolot, Meda, Ozmert, Elif N, Ascı, Ali, Erkekoglu, Pınar, Oztop, Didem B, Gumus, Hakan, Kocer-Gumusel, Belma, Yurdakok, Kadriye
Format: Article
Language:English
Subjects:
Antioxidant system
Autism
Autistic Disorder - blood
Autistic Disorder - metabolism
Benzhydryl Compounds - blood
Bisphenol A
Catalase - metabolism
Child
Emergency
Endocrine disruptors
Environmental Exposure - statistics & numerical data
Environmental Pollutants - blood
Humans
Phenols - blood
Phthalate
Phthalic Acids - blood
Selenium - metabolism
Superoxide Dismutase - metabolism
Thioredoxin-Disulfide Reductase - metabolism
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Summary:Highlights • Plasma phthalate and bisphenol A (BPA) levels were determined in autistic children. • Oxidant/antioxidant status was also evaluated. • Plasma BPA levels of children with PDD-NOS were significantly higher than control. • BPA exposure might be associated with PDD-NOS and oxidative stress. • Intracellular oxidant/antioxidant imbalance might facilitate its neurotoxicity.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2016.03.006